Abstract
EXTRACTS of vertebrate epidermis contain an antimitotic chemical messenger, called the epidermal chalone, which seems to be important in the control of epidermal mitosis1. Although the epidermal chalone is known to be tissue-specific, it is neither species nor class-specific. Chalone extracted from human skin has been found to be active on mouse epidermis1, but no experiments have yet tested the effects of skin extracts on human epidermis.
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Bullough, W. S., Laurence, E. B., Iversen, O. H., and Elgjo, K., Nature, 214, 578 (1967).
Chang, L. W., and Maibach, H. I., J. Invest. Derm., 49, 486 (1967).
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IVERSEN, O. Effect of Epidermal Chalone on Human Epidermal Mitotic Activity in vitro. Nature 219, 75 (1968). https://doi.org/10.1038/219075a0
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DOI: https://doi.org/10.1038/219075a0
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