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Mechanism of 5-Hydroxytryptamine Penetration through the Cerebrospinal Fluid–Brain Barrier

Nature volume 219, pages 72–73 (1968)Cite this article

Abstract

5-HYDROXYTRYPTAMINE (5-HT) injected into cisterna magna penetrates into brain and is converted to 5-hydroxyindoleacetic acid (5-HIAA) which can easily leave the brain tissue1,2. We have tried to elucidate the mechanism of the passage of 5-HT from the subarachnoid space into the brain.

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Author notes

  1. MARIN BULAT

    Present address: Indiana University Medical Center, Institute of Psychiatric Research, Indianapolis, Indiana

Authors and Affiliations

  1. Biology Division, Institute “Rudjer Bošković”, Zagreb, Yugoslavia

    MARIN BULAT & ZLATKO SUPEK

Authors
  1. MARIN BULAT
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  2. ZLATKO SUPEK
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BULAT, M., SUPEK, Z. Mechanism of 5-Hydroxytryptamine Penetration through the Cerebrospinal Fluid–Brain Barrier. Nature 219, 72–73 (1968). https://doi.org/10.1038/219072a0

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