Abstract
KLOEZE (Nobel Symposium II, Stockholm, 1966, Almqvist and Wiksell) showed that one of the prostaglandins, PGE1, diminished the platelet aggregation induced by ADP in platelet-rich citrated plasma of pigs and rats and in human plasma. The prostaglandin PGE2 increased this aggregation, however, but only in the plasma of pigs and rats. The effect of PGE1 in vitro and in vivo was confirmed by Emmons et al.1.
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References
Emmons, P. R., Hampton, J. R., Harrison, M. J. G., Honour, A. J., and Mitchell, J. R. A., Brit. Med. J., i, 468 (1967).
Born, G. V. R., Nature, 194, 927 (1962).
Hardisty, R. M., and Hutton, R. A., Lancet, i, 983 (1967).
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VAN CREVELD, S., PASCHA, C. Influence of the Prostaglandins E1 and E2 on Aggregation of Blood Platelets. Nature 218, 361–362 (1968). https://doi.org/10.1038/218361a0
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DOI: https://doi.org/10.1038/218361a0
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