Abstract
INJECTION of certain tranquillizing drugs during pregnancy produces defects in maze learning1, defects in both the acquisition and extinction of a conditioned avoidance response2, and lower weight1,2 in the offspring of the injected animals. These effects vary according to the period of administration, as well as the drug involved3. All the tranquillizing drugs which were used had some adverse effect, but this was not uniform. In this communication we describe attempts to extend the scope of previous work on the effects of these drugs on activity, emotionality and reaction to stress (ulceration).
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References
Hoffeld, D. R., and Webster, R. L., Nature, 205, 1070 (1965).
Hoffeld, D. R., Webster, R. L., and McNew, J., Nature, 215, 182 (1967).
DiPaolo, J. A., J. Amer. Med. Assoc., 183, 139 (1963).
Jarvik, M., and Carley, J., J. Exp. Anal. Behav., 7, 82 (1964).
Sawrey, W., and Sawrey, J., J. Comp. Physiol. Psychol., 57, 150 (1964).
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HOFFELD, D., MCNEW, J. & WEBSTER, R. Effect of Tranquillizing Drugs during Pregnancy on Activity of Offspring. Nature 218, 357–358 (1968). https://doi.org/10.1038/218357b0
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DOI: https://doi.org/10.1038/218357b0
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