Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Curare and Acetylcholine Receptor Substance

Nature volume 218, pages 330–333 (1968)Cite this article

Abstract

Curare, a drug which blocks nerve impulses at the myoneural junction, has been used in investigations aimed at the identification of the receptor substance of acetylcholine. This article reviews the progress so far.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bernard, C., Leçons sur les effets des substances toxiques et médicamenteuses, 238, Paris (1857).

    Book  Google Scholar 

  2. Langley, J. N., Proc. Roy. Soc., B, 78, 170 (1906).

    Article  ADS  CAS  Google Scholar 

  3. Dale, H. H., J. Pharmacol. Exp. Therap., 6, 147 (1914).

    CAS  Google Scholar 

  4. Loewi, O., Arch. Ges. Physiol., Pflügers, 189, 239 (1921).

    Article  Google Scholar 

  5. Loewi, O., Arch. Ges. Physiol., Pflügers, 193, 201 (1921).

    Article  Google Scholar 

  6. Nachmansohn, D., in Chagas, C., and Paes de Carvalho, A., Bioelectrogenesis, 259 (Elsevier, Amsterdam, 1961).

    Google Scholar 

  7. Ahriëns, E. J., and Simonis, A. M., Acta Physiol. Pharmac. Neerl., 11, 151 (1962).

    Google Scholar 

  8. Büchtal, P., and Lindhard, J., Acta Physiol. Scand., 4, 136 (1942).

    Article  Google Scholar 

  9. Zaimis, E., in Bovet, D., Bovet-Nitti, F., and Bettolo, G. B., Curare and Curare-like Agents, 191 (Elsevier, Amsterdam, 1958).

    Google Scholar 

  10. Župančiˇ, A. C., Acta Physiol. Scand., 29, 63 (1953).

    Article  Google Scholar 

  11. Nachmansohn, D., in Handbuch der Experimental Pharmakologie, Cholinesterase and Anticholinesterase Agents (edit. by Koelle, G. B.), 701 (Springer-Verlag, Germany, 1963).

    Book  Google Scholar 

  12. Van Rossum, J. M., and Jaramillo, J., Ciencia Mex., 21, 7 (1961).

    Google Scholar 

  13. Ahriëns, R. J., Van Rossum, J. M., and Simonis, A. M., Pharmacol. Rev., 9, 218 (1957).

    Google Scholar 

  14. Chagas, C., Penna-Franca, E., Nishie, K., Crocker, C., and Miranda, M., CR Acad. Sci., 242, 2671 (1956).

    CAS  Google Scholar 

  15. Waser, P. G., in Bovet, D., Bovet-Nitti, F., and Marini-Bettolo, G. B., Curare and Curare-like Agents, 219 (Elsevier, Amsterdam, 1958).

    Google Scholar 

  16. Waser, P. G., J. Pharmac. Pharmacol., 12, 577 (1960).

    Article  CAS  Google Scholar 

  17. Ehrenpreis, S., Science, 129, 1613 (1959).

    Article  ADS  CAS  Google Scholar 

  18. Ehrenpreis, S., Biochim. Biophys. Acta, 44, 561 (1960).

    Article  CAS  Google Scholar 

  19. Ehrenpreis, S., in Chagas, C., and Paes de Carvalho, A., Bioelectrogenesis, 378 (Elsevier, Amsterdam, 1961).

    Google Scholar 

  20. Nachmansohn, D., in Chagas, C., and Paes de Carvalho, A., Bioelectrogenesis, 259 (Elsevier, Amsterdam, 1961).

    Google Scholar 

  21. Feldberg, W., Fessard, A., and Nachmansohn, D., J. Physiol., 97, 3 (1940).

    CAS  Google Scholar 

  22. Chagas, C., Ann. Acad. Brasil. Ci., 19, 113 (1947).

    CAS  Google Scholar 

  23. Albe-Fessard, D., Chagas, C., and Martins Ferreira, H., Arch. Acad. Brasil Ci., 23, 327 (1951).

    Google Scholar 

  24. Hargreaves, A. B., in Chagas, C., and Paes de Carvalho, A., Bioelectrogenesis, 297 (Elsevier, Amsterdam, 1961).

    Google Scholar 

  25. Nachmansohn, D., and Machado, A. L., J. Neurophysiol., 6, 397 (1943).

    Article  CAS  Google Scholar 

  26. Chagas, C., Bovet, D., and Sollero, L., CR Acad. Sci., 236, 1997 (1953).

    CAS  Google Scholar 

  27. Chagas, C., Penna-Franca, E., Hassón, A., Crocker, C., Nishie, K., and Garcia, E. J., Arch. Acad. Brasil. Ci., 29, 53 (1957).

    Google Scholar 

  28. Chagas, C., in Bovet, D., Bovet-Nitti, P., and Marini-Bettolo, G. B., Curare and Curare-like Agents, 327 (Elsevier, Amsterdam, 1958).

    Google Scholar 

  29. Hassón, A., and Chagas, C., Biochim. Biophys. Acta, 36, 301 (1959).

    Article  Google Scholar 

  30. Hassón, A., and Chagas, C., in Chagas, C., and Paes de Carvalho, A., Bioelectrogenesis, 362 (Elsevier, Amsterdam, 1961).

    Google Scholar 

  31. Hassón, A., Biochim. Biophys. Acta, 65, 275 (1962).

    Article  Google Scholar 

  32. Bovet, D., in Bovet, D., Bovet-Nitti, F., and Marini-Bettolo, G. B., Curare and Curare-like Agents, 327 (Elsevier, Amsterdam, 1958).

    Google Scholar 

  33. Couceiro, A., and Akerman, M., Ann. Acad. Brasil. Ci., 20, 383 (1948).

    Google Scholar 

  34. Couceiro, A., Ann. Acad. Brasil. Ci., 22, 447 (1950).

    CAS  Google Scholar 

  35. Couceiro, A., and Freire, J. R., Ann. Acad. Brasil. Ci., 23, 443 (1951).

    CAS  Google Scholar 

  36. Winzler, R. J., in Glick, D., Methods of Biochemical Analysis, 2, 297 (Interscience, New York, 1955).

    Google Scholar 

  37. Hassón-Voloch, A., Acta Physiol. Lat. Amer., 11, 228 (1961).

    Google Scholar 

  38. Hassón-Voloch, A., Santos, M. N., Hargreaves, F. S. B., Liepin, L. L., and Soares, M. N., Acta Physiol. Lat. Amer., 16, 232 (1966).

    PubMed  Google Scholar 

  39. Hassón, A., Anais IIa Reun. Assoc. Bras. Quim. Div. Quim. Org. Bioquim. ed. Univ. Brasil, Rio de Janeiro, 143 (1962).

    Google Scholar 

  40. Hassón, A., and Yon, J., Biochim. Biophys. Acta, 50, 389 (1961).

    Article  Google Scholar 

  41. Taylor, D. B., in Ciba Found. Study Group, No. 12, Curare and Curare-like Agents, 21 (Churchill, London, 1962).

    Google Scholar 

  42. Chagas, C., in Ciba Found. Study Group, No. 12, Curare and Curare-like Agents, 2 (Churchill, London, 1962).

    Google Scholar 

  43. Hassón, A., and Liepin, L. L., Biochim. Biophys. Acta, 75, 397 (1963).

    Article  Google Scholar 

  44. Hassón, A., Liepin, L. L., and Soares, M. N., Ann. Acad. Bras. Ci., 36, 441 (1964).

    Google Scholar 

  45. Hebb, C., in Handbuch der Experimental Pharmakologie, Cholinesterase and Anticholinesterase Agents (edit. by Koelle, G. B.), 55 (Springer-Verlag, Germany, 1963).

    Book  Google Scholar 

  46. Gardiner, J. E., Biochem. J., 81, 297 (1961).

    Article  CAS  Google Scholar 

  47. Ehrenpreis, S., Nature, 194, 586 (1962).

    Article  ADS  CAS  Google Scholar 

  48. Beychock, S., Biochem. Pharmacol., 14, 1249 (1965).

    Article  Google Scholar 

  49. Waser, P. G., in Ciba Found. Study Group, No. 12, Curare and Curare-like Agents, 31 (Churchill, London, 1962).

    Google Scholar 

  50. Neet, K. E., and Friess, S. L., Arch. Biochem. Biophys., 99, 484 (1962).

    Article  CAS  Google Scholar 

  51. Friess, S. L., Durant, R. C., Chenley, J. B., and Mezzetti, T., Biochem. Pharmacol., 14, 1237 (1965).

    Article  CAS  Google Scholar 

  52. Trams, E., and Lauter, C. J., Biochim. Biophys. Acta, 83, 296 (1964).

    CAS  PubMed  Google Scholar 

  53. Paton, W. D. M., and Rang, H. P., Proc. Roy. Soc., B, 163, 1 (1965).

    Article  ADS  CAS  Google Scholar 

  54. Paton, W. D. M., Proc. Roy. Soc., B, 154, 21 (1961).

    Article  ADS  Google Scholar 

  55. De Robertis, E., Abstracts of Third Intern. Pharmacol. Cong., São Paulo 44 (1966).

Download references

Author information

Authors and Affiliations

  1. Instituto de Biofísica, Universidade Federal do Rio de Janeiro,

    AÍDA HASSÓN-VOLOCH

Authors
  1. AÍDA HASSÓN-VOLOCH
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HASSÓN-VOLOCH, A. Curare and Acetylcholine Receptor Substance. Nature 218, 330–333 (1968). https://doi.org/10.1038/218330a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/218330a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing