Abstract
THE expulsion of parasites from the alimentary tract of the host is often called the self-cure reaction1. It has recently been shown that the onset of the phase of expulsion of Nippostrongylus brasiliensis infection in the rat is sudden and the phenomenon lasts for several days2,3. The expulsion shows first order kinetics, there being a rectilinear relationship between the logarithm of the number of worms surviving and the time after infection2,3. The time of onset and the rate coefficient of this process seem to be sensitive indices of the immune status of the host, both becoming smaller with increasing degrees of immunity.
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References
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SHARP, N., JARRETT, W. Inhibition of Immunological Expulsion of Helminths by Reserpine. Nature 218, 1161–1162 (1968). https://doi.org/10.1038/2181161a0
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DOI: https://doi.org/10.1038/2181161a0
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