Abstract
Molecular weight determinations of the regulatory and catalytic chains and the amino-acid sequence of the R chain indicate that the ATCase molecule contains six copies of each chain.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Yates, R. A., and Pardee, A. B., J. Biol. Chem., 221, 757 (1956): Gerhart, J. C., and Pardee, A. B., ibid., 237, 891 (1962).
Gerhart, J. C., and Schachman, H. K., Biochemistry, 4, 1054 (1965).
Gerhart, J. C., and Schachman, H. K., Biochemistry, 7, 538 (1968).
Changeux, J. P., Gerhart, J. C., and Schachman, H. K., in Regulatory Mechanisms in Nucleic Acid and Protein Biosynthesis (edit. by Konigsberger, V. V., and Bosch, L.), 344 (Biochimica and Biophysica Acta Library, 10, Elsevier, Amsterdam).
Changeux, J. P., Gerhart, J. C., and Schachman, H. K., Biochemistry, 7, 531 (1968).
Hervé, G. L., and Stark, G. R., Biochemistry, 6, 3743 (1967).
Weber, K., J. Biol. Chem., 243, 543 (1968).
Gerhart, J. C., and Holoubek, H., J. Biol. Chem., 242, 2886 (1967).
Shapiro, A. L., Vinuela, E., and Maizel, jun., J. V., Biochem. Biophys. Res. Commun., 28, 815 (1967).
Guidotti, G., Biochim. Biophys. Acta, 42, 177 (1960).
Weber, K., and Konigsberg, W., J. Biol. Chem., 242, 3563 (1967).
Goldberger, R. F., and Anfinsen, C. B., Biochemistry, 1, 401 (1962).
Toi, K., Bynum, E., Norris, E., and Itano, H. A., J. Biol. Chem., 242, 1036 (1967).
Changeux, J. P., and Rubin, M. M., Biochemistry, 7, 553 (1968).
Monod, J., Wyman, J., and Changeux, J. P., J. Mol. Biol., 12, 88 (1965).
Kawahara, K., and Tanford, C., Biochemistry, 5, 1578 (1966).
Bovey, F. A., and Yanari, S., in The Enzymes (edit. by Boyer, P. D., Lardy, H., and Myrback, K.), 4, 63 (Academic Press, Now York, 1960).
Weber, K., Biochemistry, 6, 3144 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WEBER, K. New Structural Model of E. coli Aspartate Transcarbamylase and the Amino-acid Sequence of the Regulatory Polypeptide Chain. Nature 218, 1116–1119 (1968). https://doi.org/10.1038/2181116a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2181116a0
This article is cited by
-
Allosteric proteins: From regulatory enzymes to receptors
Rendiconti Lincei (2006)
-
Allosteric proteins after thirty years: The binding and state functions of the neuronalα7 nicotinic acetylcholine receptors
Experientia (1996)
-
A novel oligonucleotide cassette for the overproduction ofEscherichia coli aspartate transcarbamylase inBacillus stearothermophilus
Biotechnology Letters (1992)
-
The aspartate transcarbamylase domain of a mammalian multifunctional protein expressed as an independent enzyme in Escherichia coli
Molecular and General Genetics MGG (1988)
-
Enzyme binding to detect carbohydrate expression in tissue sections.
The Histochemical Journal (1987)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.