Abstract
THE ability of exponentially growing Chinese hamster cells to repair sub-lethal damage induced by X-irradiation was shown by Elkind and Sutton1. These workers showed that a dose of X-rays killed cells more efficiently when administered in one acute irradiation than when given in two fractions separated by a time interval. The survival curve for the latter (with time between the two doses as variable) showed an early rise which was interpreted by Elkind as repair, the cyclic fluctuations following repair being a result of cell-cycle associated kinetics2.
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References
Elkind, M. M., and Sutton, H., Radiat. Res., 13, 556 (1960).
Elkind, M. M., Sutton, H., and, Moses, W. B., J. Cell Comp. Physiol., 58, suppl. 1, 113 (1961).
Elkind, M. M., Alescio, T., Swain, R. W., Moses, W. B., and Sutton, H., Nature, 202, 1190 (1964).
Elkind, M. M., Whitmore, G. F., and Alescio, T., Science, 143, 1454 (1964).
Hahn, G. M., Stewart, J. R., Yang, S-J., and Parker, V., Exp. Cell Res. (in the press).
Stewart, J. R., Hahn, G. M., Parker, V., and Bagshaw, M. A., Exp. Cett Res. (in the press).
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HAHN, G. Failure of Chinese Hamster Cells to repair Sub-lethal Damage when X-irradiated in the Plateau Phase of Growth. Nature 217, 741–742 (1968). https://doi.org/10.1038/217741a0
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DOI: https://doi.org/10.1038/217741a0
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