Abstract
HUMAN heavy chains can be classified as one of four types1,2—γ1, γ2, γ3 or γ4—which have been shown by fingerprint studies to be generally similar in their Fc regions3,4. Similarities in the C-terminal regions5 and the disulphide bridges6,7 of the Fc regions of these types have also been observed. The preceding paper presents sequences around the disulphide bridges of the Fd portions of γ1 chains and gives evidence suggesting that, as in light chains8, one of the two intrachain bridges investigated is common to all IgG1 proteins, while the other is a “variable” bridge.
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PINK, J., MILSTEIN, C. Disulphide Bridges of a Human Immunoglobulin G Protein. Nature 216, 941–942 (1967). https://doi.org/10.1038/216941a0
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DOI: https://doi.org/10.1038/216941a0
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