Abstract
GLUCOCORTICOIDS have been shown to flatten the slope of peripheral disappearance of 131I-thyroxine in man1 and decrease its hepatic content in man2 and rat3. Galton and Ingbar4 have shown that deiodination of thyroxine by rat liver is mediated by two components, one of which is heat resistant and lost by leaching of liver slices in buffer and another which is heat labile and possibly an enzyme. This latter component is probably similar to the heat labile, microsomal system for degrading thyroxine in rat liver5.
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References
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ORREGO, A., KUMAR, R. & DOWLING, J. Inhibition by Cortisol of Deiodination of Thyroxine by Rat Liver in vitro. Nature 216, 820–821 (1967). https://doi.org/10.1038/216820a0
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DOI: https://doi.org/10.1038/216820a0
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