Abstract
IN studies of healing and cell replication in the epidermis, attention has been directed chiefly towards mitosis and the factors controlling it1–9. In the guinea-pig, however, the earliest evidence of an injury response is an increase in the number of cells synthesizing DNA, which can be detected as soon as 4 h after injury10. Peaks of mitotic activity occur later (24–48 h) and injury seems to impose a temporary synchrony on cell division in the epidermis, so that successive waves of DNA synthesis followed by mitoses take place. Although small peaks of mitotic activity were recorded at about 18 h, Sullivan and Epstein11 showed that the main burst of mitotic activity in humans occurred between 42–60 h.
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MANN, P. Effects of Various Substances on DNA Synthesis in Guinea-pig Skin in vitro. Nature 216, 715–716 (1967). https://doi.org/10.1038/216715a0
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DOI: https://doi.org/10.1038/216715a0
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