Abstract
BECAUSE the repair of radiation injury would seem to consume energy, chiefly in the form of ATP, we have studied the response to radiation of L cells, severely depleted of intracellular ATP. We have found that 2,4-dinitrophenol (DNP) can reduce intracellular ATP by about 90 per cent, that L cells treated with DNP for up to 8 h lose none of their reproductive integrity and that treated cells are less sensitive to radiation, particularly at a high dose.
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DALRYMPLE, G., SANDERS, J. & BAKER, M. Dinitrophenol decreases the Radiation Sensitivity of L Cells. Nature 216, 708–709 (1967). https://doi.org/10.1038/216708a0
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DOI: https://doi.org/10.1038/216708a0
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