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Antibodies to IgM in Normal Human Sera

Nature volume 216, pages 691–693 (1967)Cite this article

Abstract

THE sera of some normal human subjects contain antibodies to human IgG1, and have proved useful in investigating the genetic markers of human IgG (the Gm and Inv factors). But the IgM proteins of different human sera have also been found to differ serologically2, and investigations by means of precipitin systems have led to the designation of possible subclasses3,4. We set out to determine whether normal human sera contain antibodies to human IgM, for such reagents might help the delineation of the structure of the immunoglobulin. We have screened more than two thousand normal human sera for antibodies to IgM; forty-two were found to have such activity.

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References

  1. Ropartz, C., Lenoir, J., Hurel, R., Hemet, Y., and Breteau, G., Rev. Hématol., 13, 511 (1958).

    CAS  PubMed  Google Scholar 

  2. MacKenzie, M. R., and Deutsch, H. F., J. Immunol., 95, 87 (1965).

    CAS  PubMed  Google Scholar 

  3. Harboe, M., Deverill, J., and Godal, H. C., Scand. J. Haematol., 2, 137 (1965).

    Article  CAS  Google Scholar 

  4. Franklin, E. C., and Frangione, B., J. Clin. Invest. (Abs.), 46, 1057 (1967).

    Google Scholar 

  5. Kritzman, J., J. Lab. Clin. Med., 52, 328 (1958).

    CAS  PubMed  Google Scholar 

  6. Gold, E. R., and Fudenberg, H. H., J. Immunol. (in the press).

  7. Suzuki, T., and Deutsch, H. F., J. Biol. Chem., 242, 2725 (1967).

    CAS  PubMed  Google Scholar 

  8. Titani, K., Whitley, jun., E., Avogardo, L., and Putnam, F. W., Science, 149, 1090 (1965).

    Article  ADS  CAS  Google Scholar 

  9. Natvig, J. B., Acta Path. Microbiol. Scand., 66, 188 (1966).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco

    MALCOLM R. MACKENZIE, GAIL MACKEY & H. HUGH FUDENBERG

Authors
  1. MALCOLM R. MACKENZIE
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  2. GAIL MACKEY
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  3. H. HUGH FUDENBERG
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MACKENZIE, M., MACKEY, G. & FUDENBERG, H. Antibodies to IgM in Normal Human Sera. Nature 216, 691–693 (1967). https://doi.org/10.1038/216691a0

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