Abstract
COLCHICINE, demecolcin (N-desacetyl-N-methylcolchicine) and vinblastine are all metaphase arresting agents1. The first two compounds have been used extensively to determine various parameters of cellular dynamics, such as the mitotic index and the turnover time. In adults good agreement has been found between data obtained using colchicine and isotopes2. Vinblastine is not used to examine these cell parameters, probably because it has been shown to affect DNA synthesis3. The effect of these compounds on embryonic rats in utero has been examined. In this study, we found that the mitotic index obtained using the different compounds differed profoundly.
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WILLIAMS, J., CARPENTIERI, U. Metaphase Arresting Compounds in Embryos. Nature 216, 613–614 (1967). https://doi.org/10.1038/216613b0
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DOI: https://doi.org/10.1038/216613b0
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