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Effects of the Food Additive Butylated Hydroxytoluene on Monolayer Cultures of Primate Cells

Abstract

Inhibition of monkey kidney cell numbers by the antioxidant food additive, butylated hydroxytoluene, is caused by a rapid depression of cellular metabolism. This effect varies according to sex and may be the result of more rapid metabolism of butylated hydroxytoluene in male cells.

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References

  1. Deuel, H. J., in The Lipids, 1, 288 (Interscience Publishers Inc., New York and London, 1951).

    Google Scholar 

  2. Clement, G. H., Fd. Mf. Ingredients Survey, Jan., 10 (1966).

    Google Scholar 

  3. Frawley, J. P., Kohn, F. E., Kay, J. H., and Calandra, J. C., Food and Cosmet. Toxicol., 3, 377 (1965).

    Article  CAS  Google Scholar 

  4. Johnson, A. R., Food and Cosmet. Toxicol., 3, 371 (1965).

    Article  CAS  Google Scholar 

  5. Gaunt, I. F., Gilbert, D., and Martin, D., Food and Cosmet. Toxicol., 3, 445 (1965).

    Article  CAS  Google Scholar 

  6. Ladomery, L. G., Ryan, A. J., and Wright, S. E., J. Pharm. Pharmacol., 19, 383 (1967).

    Article  CAS  PubMed  Google Scholar 

  7. Ladomery, L. G., Ryan, A. J., and Wright, S. E., J. Pharm. Pharmacol., 19, 388 (1967).

    Article  CAS  PubMed  Google Scholar 

  8. Dacre, J. C., Biochem. J., 78, 758 (1961).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Wld. Hlth. Org. Tech. Rep. Ser., No. 144 (1958).

  10. Williams, R. T., Excerpta Med. Intern. Cong., 4, Proc. Europ. Soc. for Toxicity.

  11. McChesney, E. W., Banks, W. F., Portmann, G. A., and Crain, A. V. R., Biochem. Pharmacol., 16, 813 (1967).

    Article  CAS  PubMed  Google Scholar 

  12. Radin, N. S., in Liquid Scintillation Counting (edit. by Bell, C. G., and Hayes, F. N. (Pergamon Press, New York, Oxford and Paris, 1958).

    Google Scholar 

  13. Bray, G. A., Anal. Biochem., 1, 279 (1960).

    Article  CAS  Google Scholar 

  14. Eagle, H., and Foley, G. E., Cancer Res., 18, 1017 (1958).

    CAS  PubMed  Google Scholar 

  15. Williams, R. T., Arch. Environ. Hlth., 7, 612 (1963).

    Article  CAS  Google Scholar 

  16. Lea, C. H., J. Sci. Fd. and Agric., 4, 212 (1960).

    Article  Google Scholar 

  17. Lea, C. H., and Ward, R. J., J. Sci. Fd. and Agric., 10, 537 (1959).

    Article  CAS  Google Scholar 

  18. Studzinkski, G. P., and Ellem, K. A. O., J. Cell Biol., 23, 411 (1966).

    Article  Google Scholar 

  19. Gilbert, D., Goldberg, L., and Gangolli, S. D., Biochem. J., 103, 11P (1967).

    CAS  Google Scholar 

  20. Shah, D. O., and Schulman, J. H., J. Lipid Res., 8, 215 (1967).

    CAS  PubMed  Google Scholar 

  21. Shah, D. O., Schulman, J. H., J. Lipid Res., 8, 227 (1967).

    CAS  PubMed  Google Scholar 

  22. Snart, R. S., Biochim. Biophys. Acta Previews., 7, No. 5 (1967).

  23. Klotz, I. M., in Horizons in Biochemistry (edit. by Kasha, M., and Pullman. B.), 523 (Academic Press, London and New York, 1962).

    Google Scholar 

  24. Green, D. E., and Tzagoloff, A., J. Lipid Res., 7, 587 (1966).

    CAS  PubMed  Google Scholar 

  25. Anderson, N. B., Anest. Analg. Curr. Res., 43, 49 (1964).

    Google Scholar 

  26. Cuthbert, A. W., Pharmacol. Rev., 19, 59 (1967).

    CAS  PubMed  Google Scholar 

  27. Lea, C. H., J. Sci. Fd. and Agric., 3, 143 (1960).

    Article  Google Scholar 

  28. Golder, W. S., Ryan, A. J., and Wright, S. E., J. Pharm. Pharmacol., 14, 268 (1962).

    Article  CAS  PubMed  Google Scholar 

  29. Williams, R. T., Milburn, P., and Smith, R. L., Ann. NY Acad. Sci., 123, 110(1965).

    Article  CAS  ADS  PubMed  Google Scholar 

  30. Feuer, G., and Goldberg, L., Biochem. J., 103, 13P (1967).

    Article  CAS  Google Scholar 

  31. Catz, C., and Yaffe, S. J., J. Pharmacol. and Exp. Therap., 155, 152 (1967).

    CAS  Google Scholar 

  32. Hinton, C. L., in Fd. Addit. Control Ser., FAO, 2, 27 (1960).

    Google Scholar 

  33. Gilbert, D., and Goldberg, L., Food and Cosmet. Toxicol., 3, 417 (1965).

    Article  CAS  Google Scholar 

  34. McKay, D. G., Kaunitz, H., Csavossy, L., and Johnson, Ruth E., Metabolism, 14, 111 (1967).

    Article  Google Scholar 

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MILNER, S. Effects of the Food Additive Butylated Hydroxytoluene on Monolayer Cultures of Primate Cells. Nature 216, 557–560 (1967). https://doi.org/10.1038/216557a0

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