Abstract
ENZYMES may occur in multiple molecular forms or isozymes1, often showing tissue specific variations1–3. In different pathological conditions2 and after certain types of medication4,5, alterations in serum isozyme patterns have been observed. These findings suggest that isozymes may be valuable markers in clinical research, for example, for the identification of the tissue origin of enzymes occurring in pathological levels in various body fluids. High levels of acid phosphatase activity have been reported in the synovial fluid6 and synovial tissue7 of patients with rheumatoid arthritis. This report deals with the appearance of certain acid phosphatase isozymes in the knee-joint synovial fluid of patients with rheumatoid arthritis.
Similar content being viewed by others
Article PDF
References
Markert, C. L., and Møller, F., Proc. US Nat. Acad. Sci., 45, 753 (1959).
Lawrence, S. H., in The Zymogram in Clinical Medicine, 100 (Thomas, Springfield, 1964).
Beckman, L., in Isozyme Variations in Man, 75 (Karger, Basel, 1966).
Beckman, L., and Wetterberg, L., Acta Genet., Basel, 17, 314 (1967).
Arturson, G., Beckman, L., and Persson, B. H., Nature, 214, 1252 (1967).
Lehman, M. A., Kream, J., and Brogna, D., J. Bone Joint Surg., 46, 1372 (1964).
Luscombe, M., Nature, 197, 1010 (1963).
Ashton, G. C., and Braden, A. W. H., Austral. J. Exp. Biol. Med. Sci., 14, 248 (1969).
Beckman, L., and Beckman, G., Biochem. Genet. (in the press, 1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BECKMAN, L., BECKMAN, G. & LEMPERG, R. Appearance of Specific Acid Phosphatase Isozymes in the Synovial Fluid of Patients with Rheumatoid Arthritis. Nature 216, 274 (1967). https://doi.org/10.1038/216274a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/216274a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.