Abstract
WE have already investigated the production of immunoglobulin G (IgG) by mouse plasma cell tumour 5563 and have shown that light chains are released autonomously from polyribosomes into a pool of free light chains. The time course of incorporation of radioactive amino-acids into free light chain and the myeloma protein indicated that the pool of free light chains is small and reaches maximum radioactivity after about 10 min of incubation. It behaves as a pool with rapid turnover from which light chains appear to be incorporated into G myeloma protein molecules1,2. These findings led us to propose the possibility that the pool of free light chains controls the release of heavy chains from the polyribosomes.
Similar content being viewed by others
Article PDF
References
Askonas, B. A., and Williamson, A. R., Nature, 211, 369 (1966).
Askonas, B. A., and Williamson, A. R., Proc. Roy. Soc., B 166, 232 (1966).
Williamson, A. R., and Askonas, B. A., J. Mol. Biol., 23, 201 (1967).
Fahey, J. L., and Askonas, B. A., J. Exp. Med., 115, 623 (1962).
Hunter, W. M., and Greenwood, F. C., Nature, 194, 495 (1962).
Wortis, H. H., Taylor, R. B., and Dresser, D. W., Immunology, 11, 603 (1966).
Askonas, B. A., and Fahey, J. L., Biochem. J., 80, 261 (1961).
Shapiro, A. L., Scharff, M. D., Maizel, J. V., and Uhr, J. W., Nature, 211, 243 (1966).
Nezlin, R. S., and Kulpina, L. M., Nature, 212, 845 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ASKONAS, B., WILLIAMSON, A. Balanced Synthesis of Light and Heavy Chains of Immunoglobulin G. Nature 216, 264–267 (1967). https://doi.org/10.1038/216264a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/216264a0
This article is cited by
-
Biochemical findings in multiple sclerosis
Journal of Neurology (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.