Abstract
THE presence of calcium ions (Ca2+) in the external medium is essential for the release of acetylcholine (ACh) at peripheral synapses (superior cervical ganglion, neuromuseular junction)1–6. Evidence now suggests that ACh is a transmitter in the cerebral cortex, arid several investigators have shown that this substance is continuously released from the cerebral cortex in amounts which can be directly related to the level of cortical activity7–12. This communication describes how changes in local Ca2+ affect the spontaneous and evoked release of ACh from the cat cerebral cortex.
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RANDIĆ, M., PADJEN, A. Effect of Calcium Ions on the Release of Acetylcholine from the Cerebral Cortex. Nature 215, 990 (1967). https://doi.org/10.1038/215990a0
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DOI: https://doi.org/10.1038/215990a0
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