Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Report of a New Site-specific Cleft Palate Teratogen

Nature volume 215, pages 980–981 (1967)Cite this article

Abstract

MORE than ten chemical teratogens are now known to produce cleft palate in various species of Rodentia. All these, however, show their teratogenic potential by a widespread embryopathy of which cleft palate is but one facet of a generalized teratogenic response; little or no site-specificity of action or anatomical localization occurs .

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Trasler, D. G., Lancet, i, 606 (1965).

  2. Larsson, K. S., Ericson, B., and Bostrom, H., Acta. Morphol. Neerl. Scand., 6, 35 (1964).

    CAS  Google Scholar 

  3. King, C. T. G., Science, 141, 353 (1963).

    Article  ADS  CAS  Google Scholar 

  4. Nishimura, H., and Nakai, K., Science, 127, 877 (1958).

    Article  ADS  CAS  Google Scholar 

  5. Fraser, F. C., and Fainstat, T. D., Pediatrics, 8, 527 (1951).

    CAS  Google Scholar 

  6. Gillman, J., Gilbert, C., and Gillman, T., South Afr. J. Med. Sci., 13, 47 (1948).

    CAS  Google Scholar 

  7. Haskin, D., Anat. Rec., 102, 493 (1948).

    Article  CAS  Google Scholar 

  8. Cohlan, S., Pediatrics, 13, 6 (1954).

    Google Scholar 

  9. Hutton, E. M., Austral. Inst. Agric. Sci. (N.S.W. Brch.), 15 (1964).

  10. Emmel, M. W., and Ritchey, G. E., J. Amer. Soc. Agric., 33, 675 (1941).

    Article  Google Scholar 

  11. Nordfelt, S., Henke, L. A., Morita, K., Matsumoto, H., Takahashi, M., and Younge, O. R., Univ. Hawaii College of Agric. Tech. Bull. No. 15, 1 (1952).

  12. Freyre, R. H., and Warmke, H. E., Ann. Rep. Fed. Exp. Stn. Puerto Rico, 21 (1952).

    Google Scholar 

  13. Jeganathan, P., Trop. Agric., 109, 297 (1953).

    Google Scholar 

  14. Hutton, E. M., Windrum, G. M., and Kratzing, C. C., J. Nutrit., 64, 321 (1958).

    CAS  Google Scholar 

  15. Hutton, E. M., Windrum, G. M., and Kratzing, C. C., J. Nutrit., 65, 429 (1958).

    CAS  Google Scholar 

  16. Pearn, J. H., and Vickers, T. H., Brit. J. Exp. Path., 47, 186 (1966).

    CAS  Google Scholar 

  17. Walker, B. E., Science, 130, 981 (1959).

    Article  ADS  Google Scholar 

  18. Trasler, D. G., Walker, B. E., and Fraser, F. C., Science, 124, 439 (1956).

    Article  ADS  Google Scholar 

  19. Feild, L. E., Kreshover, S. J., and Lieberman, J. E., J. Dent. Res., 39, 1240 (1960).

    Article  CAS  Google Scholar 

  20. Ingalls, T. H., Curley, F. J., and Prindle, R. A., New Engl. J. Med., 247, 758 (1952).

    Article  CAS  Google Scholar 

  21. Russell, L. B., and Russell, W. L., J. Cell. Comp. Physiol., 43, 103 (1954).

    Article  CAS  Google Scholar 

  22. Peter, K., Ergebn. Anat. Entw. Gesch., 25, 448 (1924).

    Google Scholar 

  23. Fraser, F. C., Walker, B. E., and Trasler, D. G., Pediatrics, 19, 782 (1957).

    CAS  Google Scholar 

  24. Burston, W. R., Ann. Roy. Col. Surg. Eng., 25, 225 (1959).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Medical School, Brisbane, Queensland

    JOHN H. PEARN

Authors
  1. JOHN H. PEARN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PEARN, J. Report of a New Site-specific Cleft Palate Teratogen. Nature 215, 980–981 (1967). https://doi.org/10.1038/215980a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/215980a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing