Abstract
4-NITROQUINOLINE-1-OXIDE (NQO), a simple bicyclic compound which was synthesized by Ochiai in 1945, is a potent carcinogen. Application of NQO to the skin of mice, rats or hamsters has been shown to induce local tumours1–5 and also neoplasms of lung6–8, stomach9, uterus10 and the lymphatic system11. The present report describes the unexpected induction of epithelial tumours of the tongue in mice following the application of NQO and croton oil to the dorsal skin; the doses of these two agents were insufficient to induce more than a few tumours of the treated skin or any neoplasms at other sites. Similar findings have not previously been encountered in this laboratory in numerous experiments in which known carcinogens have been applied to mouse skin.
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CARTER, R., HEATHCOTE, N. & ROE, F. Unusual Susceptibility of Lingual Epithelium to Tumour Induction by 4-Nitroquinoline-1-oxide. Nature 215, 549–550 (1967). https://doi.org/10.1038/215549a0
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DOI: https://doi.org/10.1038/215549a0
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