Abstract
WE have investigated whether or not pre-treatment with a sub-cellular fraction containing transplantation antigens can increase survival of skin allografts across the H-2 histocompatibility locus in inbred adult mice. Graft survival was assessed by histological scoring at a standard time interval, rather than by relying on cross evaluation of graft rejection. Congenic resistant strains of mice were used so as to minimize non-H-2 antigenic disparity between donor and recipient. C57BL10/SnJ mice (H-2b) were used as donors of antigen and skin, and B10D2/SnJ mice (H-2d) as recipients. All mice were obtained from the Jackson Laboratory, Bar Harbor, Maine, and were males between 10 and 30 weeks of age.
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MUNSTER, A., WHEELER, H. & CORSON, J. Modification of the Skin Allograft Response across the H-2 Locus by Pre-treatment with Transplantation Antigens. Nature 215, 539–540 (1967). https://doi.org/10.1038/215539a0
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DOI: https://doi.org/10.1038/215539a0
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