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Use of Human Lymphocytes in Studies of Drug Action

Nature volume 215, pages 538–539 (1967)Cite this article

Abstract

LYMPHOCYTES from venous blood synthesize immunoglobulins1 and a wide range of other proteins2. Lymphocyte suspensions are a useful preparation for studying the effects of drugs on protein synthesis in vitro. Their value has been enhanced by using a medium free of plasma, so that substances in the plasma which affect protein synthesis3 can be avoided. Also interactions of drugs with plasma proteins are avoided; alternatively it is possible to detect modifications of the effects of drugs by substances present in the plasma.

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Authors and Affiliations

  1. Department of Medicine, University of Adelaide, Queen Elizabeth Hospital, Woodville, South Australia

    J. L. SMITH & I. J. FORBES

Authors
  1. J. L. SMITH
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  2. I. J. FORBES
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SMITH, J., FORBES, I. Use of Human Lymphocytes in Studies of Drug Action. Nature 215, 538–539 (1967). https://doi.org/10.1038/215538a0

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