Abstract
IT is generally accepted that the genetic determinant governing penicillin resistance in Staphylococcus aureus is located on an extra-chromosomal fragment1,2. This genetic determinant may exist in two alternative states, either as an extrachromosomal element or integrated into the chromosome3,4. Strains of staphylococci which are resistant to penicillin are often found to be resistant to mercuric chloride5. In addition, there is a genetic relationship between penicillin resistance and the chromosomal loci which govern the ability to synthesize methionine6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Novick, R. P., J. Gen. Microbiol., 33, 121 (1963).
Harmon, S. A., and Baldwin, J. N., J. Bact., 87, 593 (1964).
Asheshov, E. H., Nature, 210, 804 (1966).
Poston, S. M., Nature, 210, 802 (1966).
Richmond, M. H., and John, M., Nature, 205, 1360 (1964).
Harmon, S. A., Baldwin, J. N., Tien, W., and Critz, D. B., Canad. J. Microbiol., 12, 973 (1966).
Humbert, R. D., and Baldwin, J. N., Bact. Proc., 63, 31 (1963).
Pattee, P. A., and Baldwin, J. N., J. Bact., 82, 875 (1961).
Weaver, J. R., and Pattee, P. A., J. Bact., 88, 574 (1964).
Hirota, Y., Proc. Soc. Exp. Biol. and Med., 46, 57 (1960).
Jacob, F., Brenner, S., and Cuzin, F., Cold Spring Harbor Symp. Quant. Biol., 28, 329 (1963).
May, J. W., Houghton, R. H., and Perret, C. J., J. Gen. Microbiol., 37, 157 (1964).
Novick, R. D., and Richmond, M. H., J. Bact., 90, 467 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MILLER, M., HARMON, S. Genetic Association of Determinants controlling Resistance to Mercuric Chloride, Production of Penicillinase and Synthesis of Methionine in Staphylococcus aureus. Nature 215, 531–532 (1967). https://doi.org/10.1038/215531a0
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1038/215531a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.