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Genetic Association of Determinants controlling Resistance to Mercuric Chloride, Production of Penicillinase and Synthesis of Methionine in Staphylococcus aureus

Abstract

IT is generally accepted that the genetic determinant governing penicillin resistance in Staphylococcus aureus is located on an extra-chromosomal fragment1,2. This genetic determinant may exist in two alternative states, either as an extrachromosomal element or integrated into the chromosome3,4. Strains of staphylococci which are resistant to penicillin are often found to be resistant to mercuric chloride5. In addition, there is a genetic relationship between penicillin resistance and the chromosomal loci which govern the ability to synthesize methionine6.

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MILLER, M., HARMON, S. Genetic Association of Determinants controlling Resistance to Mercuric Chloride, Production of Penicillinase and Synthesis of Methionine in Staphylococcus aureus. Nature 215, 531–532 (1967). https://doi.org/10.1038/215531a0

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