Abstract
THERE have been numerous descriptions of the successful use of mixtures of antibiotics and atabrine in preventing the emergence of resistant strains of Staphylococcus aureus and Escherichia coli1–4. When a sensitive strain of these organisms was subcultured in an antibiotic, however, the mixture of antibiotic and atabrine was no longer effective in eliminating resistance.
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References
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WARREN, G., GREGORY, F., HEALY, EM. et al. Effect of Mixtures of Atabrine and Antibacterial Agents on the Emergence of Resistant Strains of Mycobacterium tuberculosis. Nature 215, 526–527 (1967). https://doi.org/10.1038/215526b0
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DOI: https://doi.org/10.1038/215526b0
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