Abstract
IN recent communications concerning the tertiary structure of ribonuclease two very different space models of this molecule were presented1,2. I wish to point out that, in circumstances such as these, a choice can be made between alternative structures or details of structures by a method based on a statistical matching of a given sequence of amino-acids with the sequences of proteins of known tertiary structure3. This method has been refined (my unpublished work) so that for every amino-acid position along the chain which is analysed the probability of that amino-acid belonging to an α-helical segment can be calculated.
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PERITI, P. Attempt to locate the α-Helical Segments of Ribonuclease. Nature 215, 509 (1967). https://doi.org/10.1038/215509a0
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DOI: https://doi.org/10.1038/215509a0
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