Abstract
IN many cell types differentiation is closely associated with the end of DNA synthesis. The differentiation of muscle cells is a typical example. The formation of muscle fibres takes place by the successive fusion of mononucleated myoblasts into ribbon like cells, containing as many as several hundred nuclei. After fusion, the nuclei within the fibres do not synthesize DNA, do not undergo mitosis1–4 and apparently are also restricted in RNA synthesis5,6.
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YAFFE, D., GERSHON, D. Multinucleated Muscle Fibres: Induction of DNA Synthesis and Mitosis by Polyoma Virus Infection. Nature 215, 421–424 (1967). https://doi.org/10.1038/215421a0
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DOI: https://doi.org/10.1038/215421a0
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