Abstract
IT has already been found that the ribonuclease activities of serum and urine of patients with chronic granulocytic leukaemia show characteristic variations related to this disease1. The behaviour of this enzyme in leukaemic leucocytes, however, has not been thoroughly studied. Recently, Ressler et al.2 have demonstrated the presence of two electrophoretically separable ribonuclease fractions in leukaemic leucocytes. The present work is connected with the isolation and preliminary characterization of ribonucleases from chronic granulocytic leukaemia leucocytes. Some data concerning purification procedure have been presented earlier3.
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References
Aleksandrowicz, J., Naskalski, J., Sznajd, J., and Urbańczyk, J., Acta Medica Polona, 7, 299 (1966).
Ressler, N., Olivero, E., Thompson, G. R., and Joseph, R. R., Nature, 210, 695 (1966).
Naskalski, J., and Sznajd, J., Abstracts of Third Meeting of FEBS Warsaw, F–217 (1966).
Anfinsen, C. B., Redfield, R. R., Choate, W. L., Page, J., and Carrol, W. R., J. Biol. Chem., 207, 201 (1954).
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NASKALSKI, J., SZNAJD, J. Ribonucleases of Chronic Granulocytic Leukaemia Leucocytes. Nature 215, 414–415 (1967). https://doi.org/10.1038/215414a0
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DOI: https://doi.org/10.1038/215414a0
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