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Immunological Reactivity of Peptides related to Angiotensin

Nature volume 215, pages 395–397 (1967)Cite this article

Abstract

THE production of antibodies to angiotensin II has made measurement of this peptide by radioimmunoassay possible1. While this procedure is extremely sensitive, the specificity of the method is determined by the degree to which related forms of the molecule will react with the same antiserum and thus register as angiotensin II in the assay. Because the measurement of angiotensin II in body fluids is of cardinal importance in the elucidation of the role of the renin–angiotensin system in physiological processes such as vascular reactivity and aldosterone biosynthesis, it is essential to determine whether the biologically active octapeptide is specifically estimated by the results obtained from radioimmunoassay.

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Authors and Affiliations

  1. Department of Medicine, Monash University, Prince Henry's Hospital, Melbourne

    K. J. CATT

  2. Howard Florey Laboratories of Experimental Physiology, University of Melbourne,

    J. P. COGHLAN & BARBARA ROMBERG

Authors
  1. K. J. CATT
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  2. J. P. COGHLAN
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  3. BARBARA ROMBERG
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CATT, K., COGHLAN, J. & ROMBERG, B. Immunological Reactivity of Peptides related to Angiotensin. Nature 215, 395–397 (1967). https://doi.org/10.1038/215395a0

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