Abstract
THE discovery of small virus particles resembling AAV1 in preparations of the simian adenoviruses SV11, SV15 and SV34 (refs. 1–4) suggested that these agents might be widely distributed among the simian adenovirus group. We therefore examined electron microscopic preparations1 of several recognized simian adenoviruses for the presence of these agents and tested hyperimmune simian adenovirus antisera for the presence of complement-fixing (CF) arid precipitating antibodies to AAV-1 (ref. 5), a serotype first isolated from a simian adenovirus stock1. In addition, it was of interest to determine whether normal monkey sera contained antibodies to AAV-1 and whether the presence of these antibodies would correlate with the presence of adenovirus antibodies.
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RAPOZA, N., ATCHINSON, R. Association of AAV-1 with Simian Adenoviruses. Nature 215, 1186–1187 (1967). https://doi.org/10.1038/2151186a0
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DOI: https://doi.org/10.1038/2151186a0
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