Abstract
CREATINE kinase from various species has always been found to have a molecular weight of about 80,000 (ref. 1) and to be composed of two subunits2–4, The subunits are of two types, one forming the enzyme (BB) found in brain and the other forming the enzyme (MM) found in the white fibres of skeletal muscle. A third, hybrid enzyme composed of one each of the two subunits (BM) is found in heart muscle and the red fibres of skeletal muscle3. Thus, in vertebrates, a particular enzyme type appears to be associated with the function of a particular organ or cell type.
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MORELAND, B., WATTS, D. Molecular Weight Isoenzymes of Arginine Kinase in the Mollusca and their Association with Muscle Function. Nature 215, 1092–1094 (1967). https://doi.org/10.1038/2151092a0
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DOI: https://doi.org/10.1038/2151092a0
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