Abstract
THERE is some evidence that histones inhibit synthesis of DNA-dependent RNAs and thereby regulate genetic activity1–3. If this is so they should influence embryonic development by interfering with the differential expression of genetic activity. The effects of calf thymus histone fractions on the development of the chick embryos seem to depend on the stage chosen for treatment while those of poly-L-lysine do not4,5. Such effects are presumably caused by histones complexing with cytoplasmic molecules such as those concerned in embryonic inductions which appear in a sequential order during development6.
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SHERBET, G., LAKSHMI, M. Loss of Neural Inductive Capacity of the Chick Primary Organizer by Treatment with Histone and its Restoration by Follicle-stimulating Hormone. Nature 215, 1089–1090 (1967). https://doi.org/10.1038/2151089a0
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DOI: https://doi.org/10.1038/2151089a0
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