Abstract
MILLER1 has reported a lack of development of lymphoid tissue in mice after neonatal thymectomy. These mice had a low lymphocyte count in the peripheral blood, and both spleen and lymph nodes failed to develop germinal centres and only a few plasma cells were found in them. In addition, he found that allogeneic skin which was rejected in 10 or 12 days by normal mice grafted when 5 days old survived and nourished for more than 2 months in animals thymectomized at birth. On the other hand, animals thymectomized at birth which received a syngeneic homograft of thymus at the age of 3 weeks were able to reject allogeneic skin homografts like normal intact animals.
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REESE, A., ISRAEL, M. Use of Tissue Culture to restore Immunological Competence to the Neonatally Thymectomized Mouse. Nature 215, 1085–1086 (1967). https://doi.org/10.1038/2151085a0
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DOI: https://doi.org/10.1038/2151085a0
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