Abstract
EXCESSIVE amounts of copper accumulate within the tissues in Wilson's disease (hepatolenticular degeneration). Cirrhosis is believed to be an inevitable consequence of chronic copper toxicity1. Attempts to produce equivalent hepatic dysfunction and cirrhosis in experimental animals by copper poisoning have been unsuccessful, however2.
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GOLDFISCHER, S. Demonstration of Copper and Acid Phosphatase Activity in Hepatocyte Lysosomes in Experimental Copper Toxicity. Nature 215, 74–75 (1967). https://doi.org/10.1038/215074a0
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DOI: https://doi.org/10.1038/215074a0
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