Abstract
THE principal biological parameters which have been used in defining neoplastic transformation induced in vitro are growth with a loss of contact inhibition1; continuous growth in culture; growth in semi-solid agar2; and the capacity of transformed progeny to form tumours in isogenic hosts. Several of these characteristics have been correlated with the capacity of cells transformed by chemical3 and by viral4 carcinogens to produce tumours. The findings reported here lend support to the original observations of Berwald and Sachs3,5 who presented evidence for a hydrocarbon carcinogen directed conversion of normal hamster cells in culture to a neoplastic state.
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References
Abercrombie, M., and Ambrose, E. J., Cancer Res., 22, 525 (1962).
MacPherson, I., and Montagnier, L., Virology, 23, 291 (1964).
Berwald, Y., and Sachs, L., J. Nat. Cancer Inst., 35, 661 (1965).
Hare, J. D., Proc. Amer. Assoc. Cancer Res., 7, 28 (1966).
Berwald, Y., and Sachs, L., Nature, 200, 1182 (1963).
Alfred, L., Proc. Amer. Assoc. Cancer Res., 7, 2 (1966).
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ALFRED, L. Chemical Carcinogen-induced Alterations in the Potentials of Cultured Animal Cells. Nature 214, 732–734 (1967). https://doi.org/10.1038/214732a0
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DOI: https://doi.org/10.1038/214732a0
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