Abstract
THE possibility that mammary tumour virus (MTV) and lymphatic leukaemia virus (LLV) may interfere with each other in mice was suggested by the findings that: (1) RILL mice, a strain carrying MTV in which there is a high incidence of mammary tumours, also carry “inhibitors” of MTV in their milk1, show a spontaneous tendency to lose MTV2, and develop a number of lymphoid tumours when free from MTV3. (2) Factors are present in the RIII strain which delay the progression of mammary tumours. Tumours of this strain show long periods of “pregnancy dependence”, that is, a very slow progression towards autonomous growth4–6. In this respect RIII mice differ significantly from MTV-carrying C3H strain, the tumours of which rapidly progress7,8. (3) Factors which delay progression of mammary tumours in the RIII strain are extrachromosomal and are transmitted through the milk together with MTV. When low-tumour BALB/c mice, supposedly free from virus, are foster-nursed by RIII and then maintained as an inbred line for generations, this line (BALB/cf(RIII)) shows in breeding females a high incidence of mammary tumours the behaviour of which closely resembles that of RIII tumours9,10. Conversely, the behaviour of mammary tumours in BALB/c mice foster-nursed by C3H (BALB/cf (C3H)) closely approaches that of C3H tumours11. (4) A high incidence of lymphatic leukaemia has unexpectedly been observed in BALB/cf(RIII) mice, especially in males and virgin females12–14. In contrast, however, the incidence of leukaemia in BALB/c, C3H and BALB/cf(C3H) mice is low14. (5) In BALB/cf(RIII) females there is repulsion between mammary tumours and leukaemia14–15. (6) A cell-free leukaemogenic agent has been demonstrated in BALB/cf(RIII) mice15.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Moore, D. H., in Tumors Induced by Viruses: Ultrastructural Studies (edit. by Dalton, A. J., and Haguenau, F.), 113 (Academic Press, Inc., New York, 1962).
Andervont, H. B., and Dunn, T. B., J. Nat. Cancer Inst., 28, 159 (1962).
Pullinger, B. D., and Iversen, S., Brit. J. Cancer, 14, 267 (1960).
Squartini, F., and Rossi, G., Lav. Ist. anat. e istol. pat. Perugia, 19, 105 (1959).
Squartini, F., J. Nat. Cancer Inst., 26, 813 (1961).
Squartini, F., J. Nat. Cancer Inst., 27, 911 (1962).
Squartini, F., and Severi, L., in A Ciba Found. Symp. on Tumour Viruses of Murine Origin (edit. by Wolstenholme, G. E. W., and O'Connor, M.), 82 (J. and A. Churchill, Ltd., London, 1962).
Squartini, F., Barola, E., Paoletti, I., and Rossi, G., Lav. Ist. anat. e istol pat. Perugia, 24, 29 (1964).
Squartini, F., Rossi, G., and Paoletti, I., Lav. Ist. anat. e istol. pat. Perugia, 22, 203 (1962).
Squartini, F., Rossi, G., and Paoletti, I., Nature, 197, 505 (1963).
Squaitini, F., and Rossi, G., Lav. Ist. anat. e istol. pat. Perugia, 20, 133, (1960).
Squartini, F., Lav. Ist. anat. e istol. pat. Perugia, 22, 97 (1962).
Squartini, F., and Rossi, G., Lav. Ist. anat. e. istol. pat. Perugia, 22, 185 (1962).
Squartini, F., and Rossi, G., in Atti di un Simp. su i Virus nelle Leucemie dei Mammiferi (edit. by Accademia Nazionale dei Lincei), 129 (G. Bardi, Roma, 1964).
Squartini, F., in Carcinogenesis: A Board Critique, Proc. Twentieth Ann. Symp. on Fundamental Cancer Research of the M. D. Anderson Hospital and Tumor Institute, Houston, Texas, March 7–9, 1966 (University of Texas Press, in the press).
Moloney, J. B., J. Nat. Cancer Inst, 24, 933 (1960).
Nandi, S., J. Nat. Cancer Inst., 31, 57 (1963).
Nandi, S., J. Nat. Cancer Inst., 31, 75 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SQUARTINI, F., OLIVI, M., BOLIS, G. et al. Reciprocal Interference between Mouse Mammary Tumour Virus and Leukaemia Virus. Nature 214, 730–732 (1967). https://doi.org/10.1038/214730b0
Issue Date:
DOI: https://doi.org/10.1038/214730b0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.