Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

β-Aminopropionitrile and the Mucopolysaccharides of Embryonic Chick Aortae

Nature volume 214, pages 729–730 (1967)Cite this article

Abstract

THERE is some evidence to suggest that mucopolysaccharides are involved in the connective tissue disorder of lathyrism, which is produced when certain experimental animals are exposed to the toxic effect of β-aminopropionitrile (BAPN) and related compounds. Thus, Menzies and Mills1 found that the metachromatic material of the ground substance was increased in lathyritic rat aortae, and Grant, Hathorn and Gillman2 found an increased content of hexosamine in the aortae of lathyritic rats. Levene and Gross3 showed that an abnormality of collagen can be demonstrated very soon after the injection of BAPN into chick embryos. We have investigated the aortic mucopolysaccharides in this experimental model, to see if changes in the mucopolysaccharides occurred in parallel with the changes in collagen.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Menzies, D. W., and Mills, K. W., J. Path. Bact, 73, 223 (1957).

    Article  CAS  Google Scholar 

  2. Grant, R. A., Hathorn, M., and Gillman, T., Nature, 186, 164 (1960).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Levene, C. I., and Gross, J., J. Exp. Med., 110, 771 (1959).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Levene, C. I., Brit. J. Path., 42, 89 (1961).

    CAS  Google Scholar 

  5. Manley, G., Brit. J. Exp. Path., 46, 125 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Boas, N., J. Biol. Chem., 204, 553 (1953).

    CAS  PubMed  Google Scholar 

  7. Gardell, S., Acta Chem. Scand., 7, 207 (1953).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Nuffield Department of Clinical Biochemistry, The Radcliffe Infirmary, Oxford

    G. MANLEY

  2. The Dunn Nutritional Laboratory, University of Cambridge and Medical Research Council,

    C. I. LEVENE

Authors
  1. G. MANLEY
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. I. LEVENE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MANLEY, G., LEVENE, C. β-Aminopropionitrile and the Mucopolysaccharides of Embryonic Chick Aortae. Nature 214, 729–730 (1967). https://doi.org/10.1038/214729b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/214729b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing