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Buoyant Density of Herpes Simplex Virus in Solutions of Caesium Chloride

Nature volume 214, pages 713–714 (1967)Cite this article

Abstract

PREVIOUS reports have shown that the buoyant density of herpes simplex virus in a solution of caesium chloride is genetically determined by the virus1–3. Thus plaque purified mutants obtained from a single parent and grown in the same host differ with respect to buoyant density in caesium chloride1,2. Mutants differing in buoyant density also differ, in a predictable fashion, with respect to patterns of elution from calcium phosphate gel, surface antigenic structure, stability on heating at 40° C, and plaque size2,3. These findings led to the conclusion that all these properties of the herpes virus virion are covariant and may reflect the structure of the capsid or of the envelope of the virus2,3.

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Authors and Affiliations

  1. Department of Microbiology, University of Chicago, Chicago, Illinois

    PATRICIA G. SPEAR & BERNARD ROIZMAN

Authors
  1. PATRICIA G. SPEAR
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  2. BERNARD ROIZMAN
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SPEAR, P., ROIZMAN, B. Buoyant Density of Herpes Simplex Virus in Solutions of Caesium Chloride. Nature 214, 713–714 (1967). https://doi.org/10.1038/214713a0

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  • DOI: https://doi.org/10.1038/214713a0

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