Abstract
PHYTOHAEMAGGLUTININ (PHA) has been widely used an a mitogenic agent in leucocyte cultures since its actions, as a mitogenic agent was discovered several years ago1. Little is known about the chemical structure or mechanism of action of the extract, however. Though PHA is generally thought to act as an antigenic agent in, bringing about lymphocyte transformation and division, the exact mechanism of action is unknown. Recently, Razavi2 reported cytoplasmic localization of fluorescein labelled PHA in cultured leucocytes.
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References
Nowell, P. C., Cancer Res., 20, 462 (1960).
Razavi, L., Nature, 210, 445 (1966).
Li, J. G., and Osgood, E. E., Blood, 4, 670 (1949).
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CONARD, R. Autoradiography of Leucocytes cultured with Tritiated Bean Extract. Nature 214, 709–710 (1967). https://doi.org/10.1038/214709a0
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DOI: https://doi.org/10.1038/214709a0
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