Abstract
THE tetracycline group of drugs have been found to inhibit protein synthesis in in vitro systems composed of ribosome and supernatant fractions derived from microbial as well as mammalian cells1–3. It has also been reported that chlortetracycline reduces the in vivo incorporation of 35S-methionine into liver, spleen, kidney, and gastric mucosa proteins in the rabbit4. In this report tetracycline was administered to rats and intestinal slices were later tested in vitro for incorporation of 14C-L-leucine into protein. Tetracycline clearly inhibited protein synthesis by rat jejunal slices.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Franklin, T. J., Biochem. J., 87, 449 (1963).
Franklin, T. J., Biochem. J., 90, 624 (1964).
Hierowski, M., Proc. U.S. Nat. Acad. Sci., 53, 594 (1965).
Nikolov, T. K., and Ilkov, A. T., Abstr. Fifth Intern. Congress Biochem., 9, 102 (1961).
Tye, R., and Engel, J. D., Anal. Chem., 37, 1225 (1965).
Suarez, G., and Nathans, D., Biochem. Biophys. Res. Commun., 18, 743 (1965).
Greenberger, N. J., and Ruppert, R. D., Science, 153, 315 (1966).
Greenberger, N. J., and Ruppert, R. D., Clin. Res., 14, 433 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GREENBERGER, N. Inhibition of Protein Synthesis in Rat Intestinal Slices by Tetracycline. Nature 214, 702–703 (1967). https://doi.org/10.1038/214702b0
Issue Date:
DOI: https://doi.org/10.1038/214702b0
This article is cited by
-
Hemmung der Eisenabsorption beim Menschen durch Tetracyclin
Klinische Wochenschrift (1974)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
