Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Multiple Sclerosis: Brain Immunoglobulin-G and Albumin

Abstract

The majority of brains affected by multiple sclerosis are found to contain significantly greater concentrations of gamma2 globulin (γG) than apparently normal brains. Because the concentrations of albumin are similar, it may be that γG is synthesized in the central nervous tissue of some patients with multiple sclerosis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Tourtellotte, W. W., and Parker, J. A., Trans. Amer. Neurol. Assoc., 90, 107 (1965); J. Neuropathol. and Exp. Neurol., 25, 167 (1966).

    CAS  Google Scholar 

  2. Immunoelectrophoresis Equipment Operating Manual LKB 6800A-E01 (P. O. Box Stockholm 12, Sweden, 1961).

  3. Kabat, E. A., Glusman, M., and Knaub, V., Amer. J. Med., 4, 653 (1948).

    Article  CAS  Google Scholar 

  4. Gordon, M. W., and Nurnberger, J. I., J. Histochem., 4, 84 (1956).

    Google Scholar 

  5. Allerand, C. D., and Yahr, M. D., Science, 144, 1141 (1964).

    Article  ADS  CAS  Google Scholar 

  6. Broman, T., Acta Psychiat. Neurol. Scand., Suppl. 46, 58 (1947).

  7. Broman, T., Acta Neurol. Scand., Suppl. 10, 21 (1964).

  8. Kabat, E. A., Moore, D. H., and Landow, H., J. Clin. Invest., 21, 571 (1942).

    Article  CAS  Google Scholar 

  9. McAlpine, D., Compston, N. D., and Lumsden, C. E., Multiple Sclerosis, 217 (E. and S. Livingstone, Ltd., Edinburgh, 1955).

    Google Scholar 

  10. Ibrahim, M. Z. M., in Neurochemistry (edit. by Adams, C. W. M.), 454 (Elsevier Publishing Co., New York, 1965).

    Google Scholar 

  11. Caspary, E. A., J. Neurol. Neurosurg. Psychiat., 28, 61 (1965).

    Article  CAS  Google Scholar 

  12. Tourtellotte, W. W., and Parker, J. A., Science, 154, 1044 (1966).

    Article  ADS  CAS  Google Scholar 

  13. Tourtellotte, W. W., and Parker, J. A., Trans. Amer. Neurol. Assoc., 91, 351 (1966).

    Google Scholar 

  14. Dick, G., McAlister, J. J., McKeown, F., and Campbell, A. M. G., J. Neurol. Neurosurg. Psychiat., 28, 560 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

TOURTELLOTTE, W., PARKER, J. Multiple Sclerosis: Brain Immunoglobulin-G and Albumin. Nature 214, 683–686 (1967). https://doi.org/10.1038/214683a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/214683a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing