Abstract
STARVATION produces marked alterations in cardiac metabolism, for example, decreased glucose, lactate and pyruvate metabolism accompanied by accelerated metabolism of lipids, and a raised concentration of glycogen and glucose-6-phosphate1–6. It was of interest to ascertain whether these metabolic changes are associated with modifications of the contractile behaviour of the myocardium. Accordingly, we have investigated the effects of starvation on the contractility of isolated rat atria.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Newsholme, E. A., and Randle, P. J., Biochem. J., 80, 655 (1961).
Williamson, J. R., Biochem. J., 83, 377 (1962).
Opie, L. H., Evans, J. R., and Shipp, J. C., Amer. J. Physiol., 205, 1203 (1963).
Garland, P. B., Handle, P. J., and Newsholme, E. A., Nature, 200, 169 (1963).
Williamson, J. R., Biochem. J., 93, 97 (1964).
Davis, E. J., and Quastel, J. H., Canad. J. Biochem., 42, 1605 (1964).
Gimeno, A. L., Lacuara, J. L., Gimeno, M. F., Ceretti, E., and Webb, J. L., Mol. Pharmacol., 2, 77 (1966).
Weisberg, J., and Rodbard, S., Amer. J. Physiol., 193, 466 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GIMENO, M., GIMENO, A. & LACUARA, J. Effects of Starvation on the Contractility of the Myocardium. Nature 214, 1271–1272 (1967). https://doi.org/10.1038/2141271a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2141271a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
