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Antigonadotrophic Effects of α-Methyltyrosine, Methysergide and Reserpine

Nature volume 214, pages 1268–1269 (1967)Cite this article

Abstract

RESERPINE depresses the reproductive function in adult animals and produces a striking reduction in the response of immature mice to injected gonadotrophin1,2, which does not necessarily mean that reserpine acts by diminishing gonadal responsiveness to gonadotrophin, because a similar depression of response in immature mice can be produced by hypophysectomy3,4 or by injection of barbitone5. It is probable, though not proved, that reserpine acts chiefly to reduce secretion of endogenous gonadotrophin which contributes to the response, even in immature animals.

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References

  1. Purshottam, N., Mason, M. M., and Pincus, G., Fert. Steril., 12, 346 (1961).

    Article  CAS  Google Scholar 

  2. Brown, P. S., J. Endocrinol., 35, 161 (1966).

    Article  CAS  Google Scholar 

  3. Lamond, D. R., and Emmens, C. W., J. Endocrinol., 18, 251 (1959).

    Article  CAS  Google Scholar 

  4. Brown, P. S., Acta Endocrinol., Copenhagen, 34, 375 (1960).

    Article  CAS  Google Scholar 

  5. Brown, P. S., and Wells, M., J. Endocrinol., 33, 507 (1965).

    Article  CAS  Google Scholar 

  6. Brown, P. S., J. Endocrinol., 37, 327 (1967).

    Article  CAS  Google Scholar 

  7. Spector, S., Sjoerdsma, A., and Udenfriend, S., J. Pharmacol. Exp. Therap., 147, 86 (1965).

    CAS  Google Scholar 

  8. Brown, P. S., Proc. Fifth Meeting of the Gonadotrophin Club (Livingstone, Edinburgh, in the press, 1967).

    Google Scholar 

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  1. Department of Materia Medica and Therapeutics, Medical School, University of Aberdeen,

    P. S. BROWN

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  1. P. S. BROWN
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BROWN, P. Antigonadotrophic Effects of α-Methyltyrosine, Methysergide and Reserpine. Nature 214, 1268–1269 (1967). https://doi.org/10.1038/2141268a0

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