Abstract
AN increase in the frequency of thyroid antibodies has been noted in mothers of subjects with Down's syndrome1–3. Since its previous report1, the Seattle–Winnipeg study has been expanded to 242 mothers of patients with Down's syndrome. 29 per cent had positive sera, compared with 16 per cent of an equal number of controls matched by age and sex (P < 0.005) (ref. 4).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fialkow, P. J., Uchida, I. A., Hecht, F., and Motulsky, A. G., Lancet, ii, 868 (1965).
Burgio, G. R., Severi, F., Rossoni, R., and Vaccaro, R., Lancet, i, 497 (1966).
Dallaire, R., and Flynn, D., data presented at the Third Intern. Cong. Human Genet., Chicago, 1966.
Fialkow, P. J., and Uchida, I. A., Ann. N. Y. Acad. Sci. (in the press); Fialkow, P. J., Lancet, i, 1106 (1966).
Penrose, L. S., Brit. Med. Bull., 17, 184 (1961).
Mellon, J. P., Pay, B. Y., Green, D. M., J. Ment. Defic. Res., 7, 31 (1963).
Robertson, J., Mellon, J. P., and Stewart, J. S. S., J. Ment. Defic. Res., 9, 157 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FIALKOW, P. Thyroid Antibodies, Down's Syndrome, and Maternal Age. Nature 214, 1253–1254 (1967). https://doi.org/10.1038/2141253a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2141253a0
This article is cited by
-
Mothers of children with Down syndrome have higher herpes simplex virus type 2 (HSV-2) antibody levels
Human Genetics (1986)
-
Peripheral blood ‘Rosette forming lymphocytes’ in Down's syndrome
Experientia (1974)
-
Effects of Low-dose X Irradiation on the Chromosomal Non-disjunction in Aged Mice
Nature New Biology (1973)
-
Induced chromosome aberrations in unfertilized oocytes of mice
Humangenetik (1971)
-
Non-random participation of chromosomes 13, 14 and 15 in acrocentric associations
Humangenetik (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
