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Renal Excretion of Interferon

Nature volume 214, pages 1230–1231 (1967)Cite this article

Abstract

DESPITE the intensity of research on interferons—natural virus-inhibiting proteins induced by various viral and non-viral substances1—relatively little is known about their bodily distribution, metabolism and excretion. Gresser et al.2 have recovered interferon in the urine of mice after a parenteral inoculation of interferon, and Oh has reported finding interferon in the urine of rabbits following inoculation of endotoxin. No data on amounts excreted were obtained. This communication presents data from studies of renal clearance in rabbits with (1) administered interferon; (2) interferon induced by a virus; (3) interferon induced by endotoxin.

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References

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Authors and Affiliations

  1. Department of Epidemiology and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania

    MONTO Ho & BOSKO POSTIC

Authors
  1. MONTO Ho
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  2. BOSKO POSTIC
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Cite this article

Ho, M., POSTIC, B. Renal Excretion of Interferon. Nature 214, 1230–1231 (1967). https://doi.org/10.1038/2141230a0

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