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Enhancement of the Post-irradiation Protective Action of TAB by an A-Adrenergic Blocking Agent

Nature volume 213, pages 635–636 (1967)Cite this article

Abstract

GRAM-NEGATIVE endotoxins1 or typhoid-paratyphoid A and B vaccine (TAB)2 can have a favourable influence on the acute radiation syndrome when they are administered after total-body irradiation. By stimulating excessively the release of adrenergic neurohormones5,6 or by increasing sensitivity to catecholamines7,8, however, these substances can cause reduced blood flow to the kidneys, liver and intestines5 leading to ischaemia and irreversible tissue damage. Such changes may result from the vasoconstrictor action of catecholamines.

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References

  1. Smith, W. W., Alderman, I. M., and Gillespie, R. E., Amer. J. Physiol., 192, 549 (1958).

    Article  CAS  Google Scholar 

  2. Byron, J. W., and Lajtha, L. G., Brit. J. Radiol., 39, 382 (1966).

    Article  Google Scholar 

  3. Gurney, C. W., Perspect.Biol. Med., 6, 233 (1963).

    Article  CAS  Google Scholar 

  4. Smith, W. W., Brecher, G., Budd, R. A., and Fred, S., Radiat. Res., 27, 369 (1966).

    Article  ADS  CAS  Google Scholar 

  5. Lillehei, R. C., Longerbeam, J. K., Bloch, J. H., and Manax, W. G., Clin. Pharmacol. and Therapeut., 5, 63 (1964).

    Article  CAS  Google Scholar 

  6. Hoekfelt, B., Bygdeman, S., and Sekkenes, J., in Shock, Pathogenesis and Therapy (edit. by Bock, K. D.), 151 (Springer-Verlag, Berlin, 1962).

    Google Scholar 

  7. Thomas, L., J. Exp. Med., 104, 865 (1956).

    Article  CAS  Google Scholar 

  8. Gourzis, J. T., Hollenberg, M. W., and Nickerson, M., J. Exp. Med., 114, 593 (1961).

    Article  CAS  Google Scholar 

  9. Ahlquist, L., Amer. J. Physiol., 153, 586 (1948).

    Article  CAS  Google Scholar 

  10. Levy, M. N., and Blattberg, B., in Shock (edit. by Hershey, S. G.), 65 (Little, Brown and Company, Boston, 1964).

    Google Scholar 

  11. Udenfriend, S., Cooper, J. R., Clark, C. T., and Baer, J. E., Science, 117, 663 (1953).

    Article  ADS  CAS  Google Scholar 

  12. Butterworth, K. R., and Mann, M., Brit. J. Pharmacol., 12, 415 (1957).

    CAS  PubMed  Google Scholar 

  13. Burack, R., Weiner, N., and Hagen, P., Fed. Proc., 19, 151 (1960).

    Google Scholar 

  14. Udenfriend, S., Fluorescence Assay in Biology and Medicine (Academic Press, London, 1962).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester

    JOSEPH W. BYRON

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  1. JOSEPH W. BYRON
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BYRON, J. Enhancement of the Post-irradiation Protective Action of TAB by an A-Adrenergic Blocking Agent. Nature 213, 635–636 (1967). https://doi.org/10.1038/213635a0

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