Abstract
THE pathogenicity of Gram-negative bacteria for mice has been related to their resistance to human or guinea-pig complement in vitro by Maaløe1 and by Rowley2, while Jenkin3 has suggested that serum factors are also involved in killing by macrophages. The use of human and guinea-pig complement in these experiments emphasizes the fact that no one has yet demonstrated bactericidal activity by mouse complement in vitro. Haemolytic activity, however, can be measured if special precautions are taken4.
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References
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GLYNN, A., MEDHURST, F. Possible Extracellular and Intracellular Bactericidal Actions of Mouse Complement. Nature 213, 608–610 (1967). https://doi.org/10.1038/213608a0
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DOI: https://doi.org/10.1038/213608a0
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