Abstract
Primary rat sarcomata regress, usually temporarily but occasionally completely, after the injection of nucleic acids from lymphocytes of sheep and allogeneic rats which have been immunized with tissues from the tumour to be treated. It is possible that the effect results from the strengthening of an already existing immune reaction and that it is only temporary because it is related to the life span of messenger RNA.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Delorme, E. J., and Alexander, P., Lancet, ii, 117 (1964).
Alexander, P., Delorme, E. J., and Hall, J. G., Lancet, i, 1186 (1966).
Jeejeebhoy, H. F., Delorme, E. J., and Alexander, P., Transplantation, 4, 397 (1966).
Mikulska, Z. B., Smith, C., and Alexander, P., J. Nat. Cancer Inst., 36, 29 (1966).
Niu, M. C., Cordova, C. C., and Niu, L. C., Proc. U.S. Nat. Acad. Sci., 47, 1689 (1961).
Eposito, S., Experientia, 20, 69 (1964).
Aksenova, N. N., Vakhtin, J. B., Vorobyev, V. I., and Olenov, J. M., Nature, 207, 46 (1965).
Fuks, B. B., Konstantinova, I. V., and Tsygankov, A. P., Fed. Proc., 26, T1052 (Russian original: Vestnik Akademii Meditsinskihh, 19, 28 (1965)).
Haddow, A., and Alexander, P., Lancet, i, 452 (1964).
Hall, J. G., and Morris, B., Quart. J. Exp. Physiol., 48, 235 (1963).
Kirby, K. S., Biochem. J., 96, 266 (1965).
Garvey, J. S., and Cambell, D. H., J. Exp. Med., 105, 361 (1957).
Bartfeld, H., and Juliar, J. F., Lancet, ii, 767 (1964).
Askonas, B. A., and Rhodes, J. M., Nature, 205, 470 (1965).
Fishman, M., and Adler, F. L., J. Exp. Med., 117, 595 (1963).
Cohen, E. P., Science, 152, 231 (1966).
Jankovic, B. D., and Dvorak, H. F., J. Immunol., 89, 571 (1962).
Mannick, J. A., and Egdahl, R. H., J. Clin. Invest., 43, 2166 (1964).
Hall, J. G., Morris, B., Moreno, J. D., and Bessis, M. C., J. Exp. Med. (in the press) (1967).
Coe, J. E., Feldman, J. D., and Lee, S., J. Exp. Med., 123, 267 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ALEXANDER, P., DELORME, E., HAMILTON, L. et al. Effect of Nucleic Acids from Immune Lymphocytes on Rat Sarcomata. Nature 213, 569–572 (1967). https://doi.org/10.1038/213569a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/213569a0
This article is cited by
-
Immunotherapy of human malignancies with immune RNA
World Journal of Surgery (1977)
-
Transfer of tumor specific immunity with ?immune? RNA: prospects for the treatment of human cancer
Klinische Wochenschrift (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.