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Decrease in the Concentration of Haemoglobin A2 during Erythroleukaemia

Abstract

DURING the past decade there have been several descriptions of abnormal haemoglobin in leukaemia1–4. The earliest reports emphasized the increase of foetal haemoglobin content in some cases of leukaemia in children and adults1–3. The occurrence of haemoglobin H in cases of erythroleukaemia and atypical chronic myeloid leukaemia was also reported4. In these cases no alteration in the level of the normal minor haemoglobin fraction, haemoglobin A2, was noted. We have investigated an erythroleukaemic patient with a very low level of haemoglobin A2 which developed in the course of leukaemia.

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References

  1. Singer, K., Chernoff, A. I., and Singer, L., Blood, 6, 413 (1951).

    CAS  Google Scholar 

  2. Shuster, S., Jones, J. R., and Kilpatrick, G. C., Brit. Med. J., ii, 1556 (1960).

  3. Beaven, G. H., Ellis, M. J., and White, J. C., Brit. J. Haematol., 6, 201 (1960).

    Article  CAS  Google Scholar 

  4. Beaven, G. H., Stevens, B. L., Dance, N., and White, J. C., Nature, 199, 1297 (1963).

    Article  ADS  CAS  Google Scholar 

  5. Aksoy, M., and Erdem, S., Clin. Chim. Acta, 12, 696 (1965).

    Article  CAS  Google Scholar 

  6. Kunkel, G. H., and Wallenius, G., Science, 122, 288 (1955).

    Article  ADS  CAS  Google Scholar 

  7. Huisman, T. H. J., and Dozy, A. M., Analyt. Biochem., 2, 400 (1961).

    Article  CAS  Google Scholar 

  8. Huehns, E. R., Flynn, F. V., Butler, E. A., and Shooter, E. M., Brit. J. Haematol., 6, 388 (1960).

    Article  Google Scholar 

  9. Brancati, C., Tenth Congrés de la Société Européenne d'Heématologie, Résumés des Communications, 270 (Strasbourg, 1965).

    Google Scholar 

  10. Ceppellini, R. in discussion of Hunt, J. A., and Ingram, V. M. in Biochemistry of Human Genetics (edit. by Wolstenholme, C. E. W., and O'Connor, C. M. (London: J. and A. Churchill, Ltd., 1959)).

    Google Scholar 

  11. Lee, R. C., and Huisman, T. H. J., Blood, 24, 495 (1964).

    CAS  PubMed  Google Scholar 

  12. Weatherall, D. J., The Thalassaemia Syndromes, 117 (Blackwell Scientific Publications, Oxford, 1965).

    Google Scholar 

  13. Chernoff, A. I., Ann. N.Y. Acad. Sci., 119, 557 (1964).

    Article  ADS  CAS  Google Scholar 

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AKSOY, M., ERDEM, S. Decrease in the Concentration of Haemoglobin A2 during Erythroleukaemia. Nature 213, 522–523 (1967). https://doi.org/10.1038/213522b0

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