Abstract
TUMOUR production by adenovirus type 12 in newborn hamsters inoculated subcutaneously has been confirmed in several laboratories1,2. Eddy and co-workers3 found inhibition of this tumour production in hamsters repeatedly inoculated with live adeno virus type 12 during the incubation period of tumour formation. More recently, Peries et al.4 demonstrated inhibition of the formation of adenovirus 12 induced tumours in hamsters inoculated subcutaneously with a live heterotypic virus, adeno virus type 5. No inhibition occurred, however, when killed adeno virus type 5 was used. The mechanism of tumour inhibition in both sets of experiments was not established.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Trentin, J. J., Yabe, Y., and Taylor, G., Science, 137, 835 (1962).
Huebner, R. J., Rowe, W. P., and Lane, W. T., Proc. U.S. Nat. Acad. Sci., 48, 2051 (1962).
Eddy, E. B., Grubbs, G. E., and Young, R. D., Proc. Soc. Exp. Biol., 117, 575 (1964).
Peries, J., Chaut, J. C., Canivet, M., and Boiron, M., Nature, 209, 738 (1966).
Kitamura, I., Han Hoosier, jun., G., Samper, L., Taylor, G., and Trentin, J. J., Proc. Soc. Exp. Biol., 116, 563 (1964).
Huebner, R. J., Rowe, W. P., Turner, H. C., and Lane, W. T., Proc. U.S. Nat. Acad. Sci. (Wash.), 50, 379 (1962).
Huebner, R. J., Pereira, H. G., Allison, A. C., Hollinshead, A. C., and Turner, H. C., Proc. U.S. Nat. Acad. Sci., 51, 432 (1964).
Hilleman, M. R., Stallones, R. A., Gauld, R. L., Warfield, M. S., and Anderson, S. A., Amer. J. Publ. Hlth., 47, 841 (1957).
Huebner, R. J., Casey, M. J., Chanock, R. M., and Schell, K., Proc. U.S. Nat. Acad. Sci., 54, 381 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SCHILD, G., POTTER, C. & OXFORD, J. Inhibition of Tumour Formation with Adenovirus 12 Tumour Cells in Hamsters immunized with Various Adenoviruses. Nature 213, 519–520 (1967). https://doi.org/10.1038/213519a0
Issue Date:
DOI: https://doi.org/10.1038/213519a0
This article is cited by
-
Chromosome, transplantation and tumour antigen studies of three virus-induced tumour cell lines
Archiv f�r die gesamte Virusforschung (1971)
-
Demonstration of a tumour and transplantation antigen in hamster tumours induced by an avian adenovirus (CELO)
Archiv f�r die gesamte Virusforschung (1970)
-
Immimological relationships of some oncogenic DNA viruses
Archiv f�r die gesamte Virusforschung (1969)
-
Effect of neonatal thymectomy on tumour induction by adenovirus type 12 in hamsters
Experientia (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
