Abstract
WE have recently shown that the intraperitoneal injection of reduced insulin B chain complexed with an equal amount of crystalline bovine serum albumin produces a significant hyperglycaemia in normal rats1. In accordance with the theory proposed by Ensinck, Mahler and Vallance-Owen2 we assume that this effect is due to the inhibition of endogenous insulin, activity by the complex of reduced insulin B chain and albumin.
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References
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ALBURN, H., FENICHEL, R. Hyperglycaemia induced by Insulin B Chain in Dietary Diabetes in Rats. Nature 213, 515–516 (1967). https://doi.org/10.1038/213515a0
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DOI: https://doi.org/10.1038/213515a0
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